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mouse pancreatic islets  (Jackson Laboratory)

 
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    Jackson Laboratory mouse pancreatic islets
    Mouse Pancreatic Islets, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pancreatic+islets/islets+mouse+pancreatic/us12458669-240-0-12
    Average 86 stars, based on 1 article reviews
    mouse pancreatic islets - by Bioz Stars, 2026-09
    86/100 stars

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    Related Articles

    Isolation:

    Article Title: Targeting Apollo-NADP + to Image NADPH Generation in Pancreatic Beta-Cell Organelles
    Article Snippet: .. Pancreatic islets were isolated from 8- to 12-week-old C57Bl/6J (Jackson Lab, Bar Harbor, ME, RRID: IMSR_JAX:000664) male mice by collagenase digestion (Roche Applied Science). .. Isolated islets were transferred into an Eppendorf tube (1.5 mL) containing 50 μL of RPMI islet media and 50 μL of trypsin/ethylenediamine tetraacetic acid (EDTA), immersed in a water bath at 37 °C, and shaken gently by hand for 12 min.

    Article Title: Interrupted Glucagon Signaling Reveals Hepatic-α-Cell Axis and Role for L-Glutamine in α-Cell Proliferation
    Article Snippet: .. To do this, pancreatic islets were isolated from male 8-14 week old C57Bl6/J mice (Jackson Laboratory, ME) as described previously ( Brissova et al., 2014 ). ..

    Article Title: Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells.
    Article Snippet: .. 1200–2000 pancreatic islets were isolated from 6–10 animals of male Wistar rats (250–350 g, SLC, Hamamatsu, Japan), C57BL/6J mice, or ob/ob mice (8–14 weeks old, Jackson Laboratories) by the collagenase procedure using Hanks’ solution containing 2.8 mM glucose (3, 9, 12). ..

    Article Title: RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection.
    Article Snippet: .. Pancreatic islets were isolated from 8- to 12-wk-old C57BL/6J mice (The Jackson Laboratory) and cultured as previously described (27). ..

    Article Title: Divergent effects of Sulforaphane on Basal and Glucose-Stimulated Insulin Secretion in β-Cells: Role of Reactive Oxygen Species and Induction of Endogenous Antioxidants
    Article Snippet: SFN, fatty acid-free bovine serum albumin (BSA), β-mercaptoethanol, glucose oxidase (GO), diethylmaleate (DEM), N-acetylcysteine (NAC), glutathione ethyl ester (GSH-EE), tert -Butylhydroquinone (tBHQ), potassium chloride (KCl) and glucose solution (45%) were obtained from Sigma (St. Louis, MO). .. Pancreatic islets were isolated from 9 to 12-week-old C57BL/6J mice (The Jackson Laboratories, Bar Harbor, ME) by collagenase P (Roche, Switzerland) digestion, as previously described ( 21 ). ..

    Article Title: Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages.
    Article Snippet: Transplant-associated inflammatory responses generate an unfavorable microenvironment for tissue engraftment, particularly for cells susceptible to inflammatory stress, such as pancreatic islets.. The localized delivery of anti-inflammatory agents, such as glucocorticoids, offers a promising approach to minimize the detrimental side effects associated with systemic delivery; however, the dosage must be carefully tailored to avoid deleterious responses, such as poor engraftment.. Herein, we employed a polydimethylsiloxane (PDMS)-based three-dimensional scaffold platform for the local and controlled delivery of dexamethasone (Dex).

    other:

    Article Title: RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection.
    Article Snippet: Protein extracts were isolated from pancreatic islets (C57BL/6J mice; The Jackson Laboratory) exposed to cytokines (IFN- , 1000 U/ml or IFN- , 1000 U/ml; for sources of cytokines, see above) or vehicle for 24 h. Previous studies had shown that a 24-h exposure of pancreatic islets to IFNor - was sufficient to obtain a robust protection from CVB4-mediated destruction (11).

    Article Title: Suppression of islet allogeneic immune response by indoleamine 2,3 dioxygenase-expressing fibroblasts.
    Article Snippet: Cellular Physiology Suppression of Islet Allogeneic Immune Response by Indoleamine 2,3 DioxygenaseExpressing Fibroblasts REZA B. JALILI, GINA R. RAYAT, RAY V. RAJOTTE, AND AZIZ GHAHARY* Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada V6H 3Z6 Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2N8 Endocrinology and Metabolism Research Center, Medical Sciences/University of Tehran, Tehran, Iran

    Cell Culture:

    Article Title: RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection.
    Article Snippet: .. Pancreatic islets were isolated from 8- to 12-wk-old C57BL/6J mice (The Jackson Laboratory) and cultured as previously described (27). ..



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    Evaluation of HLA mismatch impact on co-culture sensitivity and background activation. (A) Liver spheroid co-cultures comparing autologous and allogeneic (HLA-A*02 matched) effector donors. Data are presented as mean ± SD as shaded area of technical replicates (n=3) from 3 representative donor pairs (N = 3) for each HLA-A*02 background. Statistical significance relative of the autologous cultures compared to corresponding allogenic cultures two-way ANOVA with Tukey’s post-hoc test, p values are indicated for the overall comparison between autologous versus allogeneic data. (B) <t>Pancreatic</t> islet spheroid co-cultures comparing HLA-matched (4/6 alleles) and HLA-mismatched conditions. Data illustrate the increased signal-to-noise ratio in HLA-matched systems compared to the elevated background activation observed in allogeneic co-cultures. Data are presented as mean of N = 5 donors for the matched dataset and N = 4 donors for the unmatched dataset run in technical replicates (n=2).
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    Image Search Results


    Evaluation of HLA mismatch impact on co-culture sensitivity and background activation. (A) Liver spheroid co-cultures comparing autologous and allogeneic (HLA-A*02 matched) effector donors. Data are presented as mean ± SD as shaded area of technical replicates (n=3) from 3 representative donor pairs (N = 3) for each HLA-A*02 background. Statistical significance relative of the autologous cultures compared to corresponding allogenic cultures two-way ANOVA with Tukey’s post-hoc test, p values are indicated for the overall comparison between autologous versus allogeneic data. (B) Pancreatic islet spheroid co-cultures comparing HLA-matched (4/6 alleles) and HLA-mismatched conditions. Data illustrate the increased signal-to-noise ratio in HLA-matched systems compared to the elevated background activation observed in allogeneic co-cultures. Data are presented as mean of N = 5 donors for the matched dataset and N = 4 donors for the unmatched dataset run in technical replicates (n=2).

    Journal: Frontiers in Immunology

    Article Title: Translational strategy to support the first-in-human study of a TCR-like T cell bispecific with an in vitro -based safety approach

    doi: 10.3389/fimmu.2026.1736584

    Figure Lengend Snippet: Evaluation of HLA mismatch impact on co-culture sensitivity and background activation. (A) Liver spheroid co-cultures comparing autologous and allogeneic (HLA-A*02 matched) effector donors. Data are presented as mean ± SD as shaded area of technical replicates (n=3) from 3 representative donor pairs (N = 3) for each HLA-A*02 background. Statistical significance relative of the autologous cultures compared to corresponding allogenic cultures two-way ANOVA with Tukey’s post-hoc test, p values are indicated for the overall comparison between autologous versus allogeneic data. (B) Pancreatic islet spheroid co-cultures comparing HLA-matched (4/6 alleles) and HLA-mismatched conditions. Data illustrate the increased signal-to-noise ratio in HLA-matched systems compared to the elevated background activation observed in allogeneic co-cultures. Data are presented as mean of N = 5 donors for the matched dataset and N = 4 donors for the unmatched dataset run in technical replicates (n=2).

    Article Snippet: Pancreatic Islets: 3D InSight Islet Microtissues (Cat: MT-04-002-01-60, InSphero) composed of primary alpha, beta, and delta cells were used.

    Techniques: Co-Culture Assay, Activation Assay, Comparison